TNIP3 and CCN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNIP3	CCN3
Description		TNFAIP3 interacting protein 3	cellular communication network factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Inflammatory Response Toll-like Receptor 4 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Lipopolysaccharide	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Ovarian tumor domain proteases
Drugs			Insulin pork
Diseases
GWAS		Breast cancer ( 23468962) Multiple sclerosis ( 31604244)
Interacting Genes		26 interacting genes: BBS12 CCN3 CYSRT1 DAZAP2 FAM161A KPNA3 KRT40 KRTAP10-3 KRTAP10-8 LITAF LZTS2 MAGEA2 MAGEA2B MTUS2 NBPF19 NOTCH2NLA NTAQ1 PIBF1 PLSCR3 TAX1BP1 TCEANC TNIP1 TRIM55 TRIM63 UBC ZBTB8A	31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330
Entrez ID		79931	4856
HPRD ID		16268	01291
Ensembl ID		ENSG00000050730	ENSG00000136999
Uniprot IDs		Q96KP6	A0A024R9J4 P48745
PDB IDs
Enriched GO Terms of Interacting Partners?
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