PRR5L and MISP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRR5L	MISP
Description		proline rich 5 like	mitotic spindle positioning
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	TORC2 Complex	Actin Filament Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Spindle Pole Centrosome Intracellular Membrane-bounded Organelle Mitotic Spindle Astral Microtubule End
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Response To Oxidative Stress TORC2 Signaling Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Intracellular Protein Transport	Establishment Of Mitotic Spindle Orientation Cell Migration Cell Division Organelle Localization Establishment Of Centrosome Localization Mitotic Spindle Assembly Regulation Of Protein Localization To Cell Cortex
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 31361310 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879 23727859) Body shape index ( 34021172) Hip index ( 34021172) Idiopathic inflammatory myopathy ( 26362759) Inflammatory skin disease ( 25574825) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244 24076602) Photic sneeze reflex ( 27182965) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: CCDC91 EFHC1 FHL2 FHL3 HSF2BP KANK2 MAD2L2 MISP MLH1 MORN3 MTOR PHAF1 SCNM1 USP2 ZMYND12	49 interacting genes: BHLHB9 BLZF1 C19orf54 CCDC33 CDPF1 CEP76 CRBN DPH2 DPPA4 EFHC2 ENKD1 EZR FHL2 FHL5 GOLGA2 HNRNPK HSF2BP HSPB2 HSPB2-C11orf52 HSPB8 IKZF3 IRAK1BP1 KRTAP12-3 LMO1 LMO2 MAP1LC3C MORN3 MORN5 OIP5 PAX6 PFDN5 PIH1D1 PIH1D2 PNMA2 PPP1R16B PRR5L RIBC1 RINT1 RUSC1 SNW1 SOCS7 SPATC1L SPATS1 TERF1 TRAF2 TRIB3 TRIP6 VBP1 ZNF620
Entrez ID		79899	126353
HPRD ID		07854	12695
Ensembl ID		ENSG00000135362	ENSG00000099812
Uniprot IDs		B3KNU3 Q6MZQ0	Q8IVT2
PDB IDs
Enriched GO Terms of Interacting Partners?
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