MIS12 and KLHDC2

		MIS12	KLHDC2
Description		MIS12 kinetochore complex component	kelch domain containing 2
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol	Nucleus Nucleoplasm Nuclear Body Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
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Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: AKT1 CBX3 CBX5 DSN1 HSP90AA1 KLHDC2 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT	9 interacting genes: ATL1 EML2 ERO1A EZH2 MIS12 SELENOK SELENOS STRN4 USP1
Entrez ID		79003	23588
HPRD ID		12379	08824
Ensembl ID		ENSG00000167842	ENSG00000165516
Uniprot IDs		A8K1M4 Q9H081	Q9Y2U9
PDB IDs		5LSJ 5LSK	6DO3 6DO4 6DO5
Enriched GO Terms of Interacting Partners?
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