CACNA1S and RIMS2

Number of citations of the paper that reports this interaction (PubMedID 14660679)
77

Data Source:
HPRD (in vitro)

		CACNA1S	RIMS2
Description		calcium voltage-gated channel subunit alpha1 S	regulating synaptic membrane exocytosis 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex	Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	Protein Binding Small GTPase Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Cell Differentiation Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		NCAM1 interactions
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Permanent tooth development ( 21931568) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)	Cocaine dependence ( 23958962) Dietary fat liking ( 32516399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089) Parkinson's disease progression (cognitive) ( 33958783)
Interacting Genes		10 interacting genes: CCDC106 CYSRT1 KDR MEOX2 PDZD3 REL RIMS2 RYR1 SLC25A17 SRI	14 interacting genes: ABCA1 CACNA1S CD44 PABPC1 RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH
Entrez ID		779	9699
HPRD ID		00248	09436
Ensembl ID		ENSG00000081248	ENSG00000176406
Uniprot IDs		B1ALM3 Q13698	Q9UQ26
PDB IDs		2VAY 6B27	1V27 1WFG
Enriched GO Terms of Interacting Partners?
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