PCGF2 and SPDEF

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		PCGF2	SPDEF
Description		polycomb group ring finger 2	SAM pointed domain containing ETS transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Chromatin Nucleus
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		24 interacting genes: ABHD6 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RING1 RNF2 SPDEF STX2 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	13 interacting genes: AR CEP57 COX5A ENKD1 ESR1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23
Entrez ID		7703	25803
HPRD ID		10621	12176
Ensembl ID		ENSG00000277258	ENSG00000124664
Uniprot IDs		A0A024R1V6 P35227	O95238
PDB IDs			1YO5 2DKX
Enriched GO Terms of Interacting Partners?
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