SF1 and VEGFB

		SF1	VEGFB
Description		splicing factor 1	vascular endothelial growth factor B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Response To Xenobiotic Stimulus Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development
Pathways		mRNA Splicing - Major Pathway	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs		Artenimol	Aflibercept
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)	Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		60 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CDC42 CIAO1 DDX17 DUX4L9 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NFKB1 OGT OSTF1 PLSCR1 PRKG1 PRPF40A PSMA3 PUF60 RBM10 RBM17 RBM4 RBM7 RBPMS SEC23A SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 VEGFB WBP4 WDR77 WDR83 WWP2 ZNF461	11 interacting genes: ADRB2 FLT1 FOSL1 KLHL12 NRP1 SF1 TFB1M TNXB UCP2 UCP3 VEGFA
Entrez ID		7536	7423
HPRD ID		03306	03237
Ensembl ID		ENSG00000168066	ENSG00000173511
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	P49765 Q7LAP4
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	2C7W 2VWE 2XAC
Enriched GO Terms of Interacting Partners?
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