XRCC2 and WFDC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		XRCC2	WFDC1
Description		X-ray repair cross complementing 2	WAP four-disulfide core domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle	Extracellular Space
	Molecular Function	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA	Molecular_function Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process	Regulation Of Cell Growth Response To Xenobiotic Stimulus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Growth Response To Estradiol Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Mean platelet volume ( 32888494 27863252) Palmitic acid (16:0) levels ( 23362303)	Blood protein levels ( 30072576) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Systolic blood pressure (baseline) ( 33603002) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1	6 interacting genes: ETF1 EZR FOSL1 RAB40B XRCC2 ZNF677
Entrez ID		7516	58189
HPRD ID		02656	05614
Ensembl ID		ENSG00000196584	ENSG00000103175
Uniprot IDs		A0A384MEK2 O43543	Q9HC57
PDB IDs
Enriched GO Terms of Interacting Partners?
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