XRCC2 and NKIRAS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		XRCC2	NKIRAS1
Description		X-ray repair cross complementing 2	NFKB inhibitor interacting Ras like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Cytosol
	Molecular Function	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA	GTPase Activity GTP Binding
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process	I-kappaB Kinase/NF-kappaB Signaling
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Mean platelet volume ( 32888494 27863252) Palmitic acid (16:0) levels ( 23362303)	Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)
Interacting Genes		5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1	8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2
Entrez ID		7516	28512
HPRD ID		02656	06841
Ensembl ID		ENSG00000196584	ENSG00000197885
Uniprot IDs		A0A384MEK2 O43543	Q9NYS0
PDB IDs
Enriched GO Terms of Interacting Partners?
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