XRCC1 and OGG1

Number of citations of the paper that reports this interaction (PubMedID 12933815)
78

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		XRCC1	OGG1
Description		X-ray repair cross complementing 1	8-oxoguanine DNA glycosylase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex
	Molecular Function	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Damaged DNA Binding Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Single Strand Break Repair Response To Hypoxia Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Xenobiotic Stimulus Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Acute Inflammatory Response Base-excision Repair Base-excision Repair, AP Site Formation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Response To Radiation Response To Xenobiotic Stimulus Response To Light Stimulus Response To Estradiol Nucleotide-excision Repair, DNA Incision Negative Regulation Of Apoptotic Process Depurination Depyrimidination Response To Ethanol Response To Folic Acid Cellular Response To Cadmium Ion Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		20 interacting genes: APEX1 APLF APTX BRCA1 BTRC CHD1L CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I	7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1
Entrez ID		7515	4968
HPRD ID		01909	03582
Ensembl ID		ENSG00000073050	ENSG00000114026
Uniprot IDs		B2RCY5 P18887 Q59HH7	E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2	1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13
Enriched GO Terms of Interacting Partners?
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