FANCD2 and USP1

Number of citations of the paper that reports this interaction (PubMedID 15694335)
240

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		FANCD2	USP1
Description		FA complementation group D2	ubiquitin specific peptidase 1
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding DNA Polymerase Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity
	Biological Process	Homologous Chromosome Pairing At Meiosis Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Double-strand Break Repair Involved In Meiotic Recombination	Skeletal System Development DNA Repair Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination DNA Damage Response, Detection Of DNA Damage
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7	16 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K WDR48
Entrez ID		2177	7398
HPRD ID		01968	04593
Ensembl ID		ENSG00000144554	ENSG00000162607
Uniprot IDs		Q9BXW9	O94782
PDB IDs		6VAA 6VAD 6VAE 6VAF	6DO5
Enriched GO Terms of Interacting Partners?
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