UBE2V2 and TRIM5

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		UBE2V2	TRIM5
Description		ubiquitin conjugating enzyme E2 V2	tripartite motif containing 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm UBC13-MMS2 Complex Extracellular Exosome	P-body Nucleoplasm Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination	Protein Polyubiquitination Activation Of Innate Immune Response Autophagy Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Height ( 31562340)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 29403010 32888494) Serum alkaline phosphatase levels ( 33547301 29403010 33339817) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		31 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 OTUB1 RC3H1 RC3H2 RFFL RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N XIAP ZNRF1	46 interacting genes: BTBD1 BTBD2 EHHADH EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1
Entrez ID		7336	85363
HPRD ID		04300	07004
Ensembl ID		ENSG00000169139	ENSG00000132256
Uniprot IDs		A0M8W4 Q15819	Q9C035
PDB IDs		1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF	2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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