UBE2G2 and AUP1

Number of citations of the paper that reports this interaction (PubMedID 22119785)
230

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		UBE2G2	AUP1
Description		ubiquitin conjugating enzyme E2 G2	AUP1 lipid droplet regulating VLDL assembly factor
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Hrd1p Ubiquitin Ligase ERAD-L Complex Autophagosome Endoplasmic Reticulum Lipid Droplet Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Response To Virus Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Regulation Of Catalytic Activity Lipophagy ER-associated Misfolded Protein Catabolic Process Lipid Droplet Formation Protein Localization To Lipid Droplet
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN PSMG1 RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRAPPC10 TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	9 interacting genes: GPR35 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBE2G2
Entrez ID		7327	550
HPRD ID		04387	03892
Ensembl ID		ENSG00000184787	ENSG00000115307
Uniprot IDs		P60604	Q9Y679
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD	2EKF
Enriched GO Terms of Interacting Partners?
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