TYROBP and TREM1

Number of citations of the paper that reports this interaction (PubMedID 10799849)
367

Data Source:
HPRD (in vivo)

		TYROBP	TREM1
Description		transmembrane immune signaling adaptor TYROBP	triggering receptor expressed on myeloid cells 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Signaling Receptor Activity Scaffold Protein Binding
	Biological Process	Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Adaptive Immune Response Cytokine Production Involved In Immune Response Acute Inflammatory Response Humoral Immune Response Neutrophil Chemotaxis Chemokine Production Intracellular Signal Transduction Innate Immune Response Neutrophil-mediated Killing Of Gram-negative Bacterium
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall DAP12 interactions
Drugs			D-tartaric acid
Diseases
GWAS			Blood protein levels ( 30072576 29875488)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	1 interacting genes: TYROBP
Entrez ID		7305	54210
HPRD ID		04996	05472
Ensembl ID		ENSG00000011600	ENSG00000124731
Uniprot IDs		O43914 X6RGC9	K7EKM5 Q38L15 Q9NP99
PDB IDs		2L34 2L35 4WO1 4WOL	1Q8M 1SMO
Enriched GO Terms of Interacting Partners?
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