TYROBP and KLRK1

Number of citations of the paper that reports this interaction (PubMedID 12426564)
123

Data Source:
HPRD (in vivo)

		TYROBP	KLRK1
Description		transmembrane immune signaling adaptor TYROBP	killer cell lectin like receptor K1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Adaptive Immune Response Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS			Blood protein levels ( 28240269) Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3
Entrez ID		7305	22914
HPRD ID		04996	17240
Ensembl ID		ENSG00000011600	ENSG00000213809
Uniprot IDs		O43914 X6RGC9	A0A024RAP8 P26718
PDB IDs		2L34 2L35 4WO1 4WOL	1HYR 1KCG 1MPU 4PDC 4S0U
Enriched GO Terms of Interacting Partners?
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