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TSC2 and SERPINI1
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
98
Data Source:
BioGRID
(two hybrid)
TSC2
SERPINI1
Description
TSC complex subunit 2
serpin family I member 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Extracellular Space
Secretory Granule Lumen
Neuronal Cell Body
Perikaryon
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Serine-type Endopeptidase Inhibitor Activity
Biological Process
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Central Nervous System Development
Peripheral Nervous System Development
Negative Regulation Of Endopeptidase Activity
Positive Regulation Of Neuron Projection Development
Regulation Of Cell Adhesion
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Diseases
GWAS
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Eye color (saturation) (
30664655
)
Fast beta electroencephalogram (
28070124
)
Heart rate (
23534349
)
Height (
18391951
)
Hip circumference adjusted for BMI (
28552196
)
Metabolite levels (
23823483
)
Skin, hair and eye pigmentation (multivariate analysis) (
30664655
)
Interacting Genes
59 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
3 interacting genes:
PLAT
PLG
TSC2
Entrez ID
7249
5274
HPRD ID
01850
03901
Ensembl ID
ENSG00000103197
ENSG00000163536
Uniprot IDs
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
A0A0S2Z455
Q99574
PDB IDs
7DL2
3F02
3F5N
3FGQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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