TSC2 and PHLDB1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		TSC2	PHLDB1
Description		TSC complex subunit 2	pleckstrin homology like domain family B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm	Basal Cortex
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding	Protein Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy	Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases
GWAS		Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)	Adult diffuse glioma (IDH mutation) ( 32386320) Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) ( 32386320) Celiac disease ( 25920553) Cholesterol, total ( 24097068) Glioma ( 30714141 28346443 21531791 29743610 19578367) Heel bone mineral density ( 30598549 28869591) Multiple sclerosis ( 31604244) Non-glioblastoma glioma ( 28346443 29743610) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 29403010 33339817) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total cholesterol levels ( 28334899 30275531) Vitiligo ( 22951725)
Interacting Genes		59 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	6 interacting genes: FXR1 FXR2 SHANK3 SRPK2 TSC1 TSC2
Entrez ID		7249	23187
HPRD ID		01850	15128
Ensembl ID		ENSG00000103197	ENSG00000019144
Uniprot IDs		B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2	A0A024R3F4 A0A024R3H6 Q6ZUD6 Q86UU1 Q8NC75
PDB IDs		7DL2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?