TSN and UBE2K

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TSN	UBE2K
Description		translin	ubiquitin conjugating enzyme E2 K
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol	Nucleus Cytosol Filopodium Tip
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding Endonuclease Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Recombination RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Small interfering RNA (siRNA) biogenesis	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration ( 29346644) Erectile dysfunction and prostate cancer treatment ( 20932654) Food antigen IgG levels ( 24962563) Hepcidin/ferritin ratio ( 27846281) Major depressive disorder x sex interaction ( 34099189) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 34074324)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		16 interacting genes: CFC1 DVL3 FXR1 GIT2 GORASP2 LNX1 MORF4L2 NTAQ1 PICK1 PPP1R15A SDCBP SIN3A TSNAX UBE2I UBE2K ZBTB18	94 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		7247	3093
HPRD ID		08993	04165
Ensembl ID		ENSG00000211460	ENSG00000078140
Uniprot IDs		B3KRM8 Q15631	B3KSH4 B4DIZ2 P61086
PDB IDs		1J1J 3PJA 3QB5 4WYV	1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7
Enriched GO Terms of Interacting Partners?
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