UBE2K and RC3H2

Number of citations of the paper that reports this interaction (PubMedID 26489670)
13

Data Source:
BioGRID (pull down)

		UBE2K	RC3H2
Description		ubiquitin conjugating enzyme E2 K	ring finger and CCCH-type domains 2
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GO Annotations	Cellular Component	Nucleus Cytosol Filopodium Tip	P-body Cell Surface Cytoplasmic Stress Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay B Cell Homeostasis Ubiquitin-dependent Protein Catabolic Process Post-embryonic Development Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		94 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	14 interacting genes: KLHL6 TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2
Entrez ID		3093	54542
HPRD ID		04165	14726
Ensembl ID		ENSG00000078140	ENSG00000056586
Uniprot IDs		B3KSH4 B4DIZ2 P61086	A0A024R899 Q9HBD1
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7	4Z30 4Z31 4ZLC 4ZLD
Enriched GO Terms of Interacting Partners?
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