TRPC6 and TRPC3

Number of citations of the paper that reports this interaction (PubMedID 12032305)
231

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo, in vitro)

		TRPC6	TRPC3
Description		transient receptor potential cation channel subfamily C member 6	transient receptor potential cation channel subfamily C member 3
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex
	Molecular Function	Actin Binding Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Daytime nap ( 33568662) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)	Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	21 interacting genes: BBS7 CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		7225	7222
HPRD ID		04710	15999
Ensembl ID		ENSG00000137672	ENSG00000138741
Uniprot IDs		Q9Y210	Q13507
PDB IDs		5YX9 6UZ8 6UZA 7A6U	5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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