TRPC3 and ORAI1

Number of citations of the paper that reports this interaction (PubMedID 17360584)
124

Data Source:
HPRD (in vivo, in vitro)

		TRPC3	ORAI1
Description		transient receptor potential cation channel subfamily C member 3	ORAI calcium release-activated calcium modulator 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Store-operated Calcium Entry Adaptive Immune Response Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)	Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)
Interacting Genes		21 interacting genes: BBS7 CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	2 interacting genes: TRPC3 TRPC6
Entrez ID		7222	84876
HPRD ID		15999	08599
Ensembl ID		ENSG00000138741
Uniprot IDs		Q13507	A0A024RBT3 Q96D31
PDB IDs		5ZBG 6CUD 6D7L 6DJS	2MAK 4EHQ
Enriched GO Terms of Interacting Partners?
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