TRIO and MARCHF6

		TRIO	MARCHF6
Description		trio Rho guanine nucleotide exchange factor	membrane associated ring-CH-type finger 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell Projection	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Central Nervous System Development Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Proteasomal Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming
Pathways		NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		17 interacting genes: BLMH CDC42 CDC5L DAP DISC1 DNAH5 EXOC1 FLNA ITSN2 LIMS1 MARCHF6 NIPBL PRMT7 PTK2 PTPRF RAC1 RHOA	10 interacting genes: ADGRE2 BUD31 DIO2 DNAH5 MTNR1B RGS2 TRIO UBC UBE2D2 UBE2G1
Entrez ID		7204	10299
HPRD ID		03537	11095
Ensembl ID		ENSG00000038382	ENSG00000145495
Uniprot IDs		O75962	O60337
PDB IDs		1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?