TPI1 and CDKN2A

Number of citations of the paper that reports this interaction (PubMedID 16582619)
23

Data Source:
HPRD (two hybrid)

		TPI1	CDKN2A
Description		triosephosphate isomerase 1	cyclin dependent kinase inhibitor 2A
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Senescence-associated Heterochromatin Focus
	Molecular Function	Triose-phosphate Isomerase Activity Protein Binding Methylglyoxal Synthase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	RNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding NF-kappaB Binding
	Biological Process	Gluconeogenesis Glycolytic Process Methylglyoxal Biosynthetic Process Glycerol Catabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Cellular Senescence Replicative Senescence Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence
Pathways		Glycolysis Gluconeogenesis	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Drugs		Zinc N-Hydroxy-4-Phosphono-Butanamide 2-Phosphoglycolic Acid Phosphoglycolohydroxamic Acid 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid 5-fluorotryptophan 2-Carboxyethylphosphonic Acid tert-butanol Dihydroxyacetone phosphate 1,4-Dithiothreitol 3-phospho-D-glyceric acid 3-(BUTYLSULPHONYL)-PROPANOIC ACID Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278)	Abdominal aortic aneurysm ( 20622881) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 24403052 25855136) Basophil count ( 32888494) Breast cancer ( 29059683 23535729 20453838) Coronary artery calcification ( 23561647) Coronary artery disease ( 21239051 29263402 26708285) Coronary heart disease ( 21971053 17554300 21378990) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Eosinophil counts ( 32888494) Esophageal squamous cell carcinoma ( 25129146) Fasting plasma glucose ( 25187374) Glioblastoma ( 28346443) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542 19578364) Monocyte count ( 32888494 27863252) Multiple myeloma ( 27363682) Myocardial infarction ( 17478679 26708285) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443) Non-small cell lung cancer ( 31326317) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Platelet count ( 22139419 32888494 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spleen volume ( 34128465) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 32499647 20581827 19401414 17463246 30718926 17463248 17463249 23209189) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		17 interacting genes: APP BDKRB2 CCL11 CDKN2A CFL1 DDX24 EGFR HTR2C LIPT1 MAPK6 PCNA POT1 SETDB1 SP1 TERF1 UCHL5 YWHAQ	172 interacting genes: - ACLY ACTB ACTG1 ACTN4 AHNAK AKT1 ALDOB ANAPC15 ANGPTL4 ANKRA2 ANKRD12 AOPEP ARFIP2 ARNT ASPRV1 AZIN1 BAAT BCL2L1 BECN1 CA9 CARF CASC3 CCDC180 CCDC183 CCND2 CCNDBP1 CCNE1 CCNG1 CD44 CDC14B CDC42 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2B CDKN2C CENPA CRELD2 CTBP2 CTSV CYLC2 DEAF1 DNAI1 E2F1 E4F1 EEF2 EFHC2 EGR1 EPHA2 EPHA3 EXOC2 FGFR4 FN1 FRAT2 GALNT12 GAPDH GGA1 GGA3 GLIPR2 GLIS1 GLIS2 GMNN GSPT1 H2BU1 HGF HIF1A HLA-DOB HNRNPA2B1 HNRNPC HNRNPU HRAS HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 ISOC2 KAT5 LATS2 MAF1 MAP2K1 MAP2K5 MAP3K5 MAPK10 MAPK14 MAPK3 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MDM4 MMRN1 MTR MYC MYL12A NAT2 NCL NFX1 NMI NOP53 NPM1 NSD3 ORC4 PCNA PDCD6 PDGFRA PEX19 PPP1R9B PRKCA PSMC3 PTP4A3 RAF1 RASA1 RASSF1 RBM26 RIN2 RPL11 RPS7 RUVBL2 SEC61B SERTAD1 SFRP4 SIT1 SIVA1 SIX2 SLC4A1 SMARCA4 SNRPA SNRPB SOX3 SOX4 STK11 TBRG1 TDRD7 TEAD2 TERT TFDP1 TGFB1 TMEFF1 TMOD1 TP53 TP63 TPI1 TRIM28 TRIP12 TSC1 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B UBL7 USP26 VAMP1 VHL WRN YY1 ZFP91 ZGRF1 ZNF227 ZNF410 ZNF420 ZNF687 ZUP1
Entrez ID		7167	1029
HPRD ID		01833	02542
Ensembl ID		ENSG00000111669	ENSG00000147889
Uniprot IDs		P60174 Q53HE2 V9HWK1	K7PML8 P42771 Q8N726
PDB IDs		1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ 6C2G 6D43 6NLH 6UP1 6UP5 6UP8 6UPF	1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?
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