TOP1 and LSM4

  • Number of citations of the paper that reports this interaction (PubMedID 12549820)
  • 3
  • Data Source:
  • BioGRID (unspecified method)

TOP1

LSM4

Description DNA topoisomerase I LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309)
  • Antipsychotic drug-induced weight gain in schizophrenia ( 31447353)
  • Brain morphology (MOSTest) ( 32665545)
  • Cholesterol, total ( 24097068 20686565)
  • Fasting glucose ( 33402679)
  • Hemoglobin ( 32888494)
  • Hip circumference adjusted for BMI ( 34021172)
  • LDL cholesterol ( 24097068 20686565)
  • LDL cholesterol levels ( 28334899)
  • LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
  • Male-pattern baldness ( 28196072)
  • Metabolite levels ( 23823483)
  • PR interval ( 32439900)
  • Red blood cell count ( 32888494)
  • Refractive error ( 32231278)
  • Total cholesterol levels ( 28334899)
  • Urate levels ( 31578528)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes 61 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PIAS4 PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6 21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 LSM7 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 XRN1 ZBTB10
Entrez ID 7150 25804
HPRD ID 00535 06284
Ensembl ID ENSG00000198900 ENSG00000130520
Uniprot IDs P11387 Q9BVT2 Q9Y4Z0 U3KQK1
PDB IDs 1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG
Enriched GO Terms of Interacting Partners?
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