LSM4 and GAS7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LSM4	GAS7
Description		LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	growth arrest specific 7
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol Membrane Protein-containing Complex Neuron Projection U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex	Cytoplasm Actin Filament Plasma Membrane
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding PH Domain Binding	Protein Binding Actin Filament Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process RNA Splicing P-body Assembly	Actin Filament Polymerization Neuron Projection Morphogenesis
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Estimated glomerular filtration rate ( 30604766) Gastroesophageal reflux disease ( 31527586) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 LSM7 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 XRN1 ZBTB10	26 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MYBPC2 NCKAP1 NCKAP1L NCKIPSD NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A
Entrez ID		25804	8522
HPRD ID		06284	16011
Ensembl ID		ENSG00000130520	ENSG00000007237
Uniprot IDs		Q9Y4Z0 U3KQK1	O60861
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG	2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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