TNNI1 and ESRRG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNNI1	ESRRG
Description		troponin I1, slow skeletal type	estrogen related receptor gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Chromatin Nucleoplasm
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Regulation Of Striated Muscle Contraction Transition Between Fast And Slow Fiber Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Striated Muscle Contraction	Nuclear Receptor transcription pathway
Drugs			Troglitazone Diethylstilbestrol Tamoxifen Cholic Acid Afimoxifene 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE p-Cumylphenol Bisphenol A Bisphenol Z Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS			Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to drug ( 30420678) Alcohol consumption ( 23743675) Breast cancer ( 29059683) Cardiac hypertrophy ( 21348951) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom (anhedonia) (ordinal trait) ( 31530331) Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Energy expenditure (24h) ( 28476931) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) LDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 23377640) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Optic nerve measurement (cup area) ( 20395239) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sleep duration ( 25469926) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Weight ( 28552196)
Interacting Genes		48 interacting genes: ACTA1 ANKRD11 ARMC7 C2orf68 CABP2 CABP5 CCDC102B CCDC57 CCDC85B CDCA7L CEP19 CETN3 CTNNA3 DCAF11 DCC EAF1 EFCAB2 EIF1AD EIF3B ENKD1 ESRRG KIFC3 L3MBTL2 MBD3 MCRS1 MDFI MNS1 MTUS2 NEK7 PIH1D2 PIK3R3 PKD2L1 PNMA1 POLR1C PRKAB2 SAT1 SCNM1 SPANXN2 SYCE1L TNNC1 TNNT1 TNNT2 TPM3 TRIM41 TRIM55 TRIM63 USP20 ZNF76	59 interacting genes: ADCY4 APP ARHGEF15 ATM BPHL C22orf23 CALM1 CAMK2G CCDC33 DAXX DEUP1 DUT EBP EFHC2 ESRRA ESRRB EXOSC7 FAM107A FAM9A FASTK HGS HIF1A KIFC3 LRRK2 MARK1 MCC MEOX2 MFHAS1 MRM1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PAX6 PNRC1 PNRC2 POMC PPARGC1A PPARGC1B PROX1 PSMC5 RBIS REL RINT1 SHTN1 SNIP1 SP1 SRA1 SRPK1 SUMO1P1 TLE1 TNNI1 TNNI2 TRERF1 TULP3 UBL7 VAX1 ZNF438
Entrez ID		7135	2104
HPRD ID		01842	04274
Ensembl ID		ENSG00000159173	ENSG00000196482
Uniprot IDs		P19237	B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs			1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67 6K3N 6KNR
Enriched GO Terms of Interacting Partners?
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