TMSB4XP6 and PTGIS

		TMSB4XP6	PTGIS
Description		TMSB4X pseudogene 6	prostaglandin I2 synthase
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function		Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process		Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		5 interacting genes: ADAMTSL4 ALAS1 PTGIS SLC9A8 TRIM27	10 interacting genes: APP ARFGEF2 BTF3 GMFG GNAS LTB4R2 PKHD1 PTGS1 PTGS2 TMSB4XP6
Entrez ID		7120	5740
HPRD ID		10275	09046
Ensembl ID			ENSG00000124212
Uniprot IDs			Q16647
PDB IDs			2IAG 3B6H
Enriched GO Terms of Interacting Partners?
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