PTGIS and PKHD1

		PTGIS	PKHD1
Description		prostaglandin I2 synthase	PKHD1 ciliary IPT domain containing fibrocystin/polyductin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane	Chromosome, Centromeric Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cilium Integral Component Of Membrane Apical Plasma Membrane Anchored Component Of External Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle 9+0 Non-motile Cilium
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	Establishment Of Mitotic Spindle Orientation Kidney Development Regulation Of Cell-matrix Adhesion Epithelial Cell Morphogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of TOR Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Homeostatic Process Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Component Movement Establishment Of Centrosome Localization Negative Regulation Of Protein Kinase B Signaling Cilium Assembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of Planar Polarity Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Cholangiocyte Proliferation
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Adult body size ( 32376654) Alcohol use disorder ( 30940813) Body size at age 10 ( 32376654) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Coffee consumption ( 31046077) Diastolic blood pressure ( 28135244 27841878) Epigenetic age acceleration in alcohol use disorder ( 31466081) Estimated glomerular filtration rate ( 31152163) Fruit consumption ( 32066663) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 24002674 29785010 31959993 30054594 29235454) Keratoconus ( 33649486) Longevity ( 30294719) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 17903305) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Tea consumption ( 31046077) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197) Weight loss (gastric bypass surgery) ( 23633212)
Interacting Genes		10 interacting genes: APP ARFGEF2 BTF3 GMFG GNAS LTB4R2 PKHD1 PTGS1 PTGS2 TMSB4XP6	2 interacting genes: CAMLG PTGIS
Entrez ID		5740	5314
HPRD ID		09046	05987
Ensembl ID		ENSG00000124212	ENSG00000170927
Uniprot IDs		Q16647	P08F94
PDB IDs		2IAG 3B6H
Enriched GO Terms of Interacting Partners?
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