THRSP and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		THRSP	PALB2
Description		thyroid hormone responsive	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	DNA Binding Protein Binding
	Biological Process	Lipid Metabolic Process Response To Bacterium Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Biosynthetic Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Carnitine metabolism	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Tourette syndrome ( 30818990)	Bipolar disorder ( 17554300)
Interacting Genes		26 interacting genes: AKT1 AURKA BAG4 BCAR3 BRMS1 ERBB2 FGFR4 FZR1 HMMR IGF1R INCA1 KRAS LSP1 PALB2 PARP1 PIK3CA PTPN1 RB1CC1 SLAMF7 SMAD4 STK11 TEPSIN TGFB1 TSG101 WT1 ZMYND12	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		7069	79728
HPRD ID		03566	07966
Ensembl ID		ENSG00000151365	ENSG00000083093
Uniprot IDs		Q92748	H3BN63 Q86YC2
PDB IDs			2W18 3EU7
Enriched GO Terms of Interacting Partners?
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