THRB and PDE4DIP

		THRB	PDE4DIP
Description		thyroid hormone receptor beta	phosphodiesterase 4D interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Enzyme Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process	Cellular Protein-containing Complex Assembly Regulation Of Golgi Organization
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Colorectal cancer ( 34062886) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)	Capecitabine sensitivity ( 22864933) Cutaneous mastocytosis ( 32752121) Macrovascular complications in type 2 diabetes ( 33430853) Mastocytosis ( 32752121)
Interacting Genes		59 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PDE4DIP PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3	95 interacting genes: ADH1B AEN AKTIP ANKRD11 ARNT2 BYSL C1orf109 CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CHD1L CLIP4 CWF19L2 EGR2 EIF4E2 FAM161A FAM50B FAM74A4 FCHSD2 FES FHL1 GADD45G GBE1 GFI1B GNRHR2 GOLGA5 GOLGA8EP GOLGA8F HAUS1 HOXB5 HOXC8 ITSN2 KDM1A KLC3 KLC4 KRAS KRT1 KRT18 KRT31 LAMTOR3 LENG1 LIN37 LMO4 MAPRE3 MIF4GD MTUS2 MYBPC2 MYOM1 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 PYGM RBM8A RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 THRB TK1 TMOD4 TNIK TRAF4 TULP3 UTP14C VAC14 ZBTB24 ZBTB38 ZBTB4 ZDHHC17 ZFYVE21 ZKSCAN3 ZNF124 ZNF408 ZNF410 ZNF414 ZNF512B ZNF581 ZNF587 ZNF696 ZSCAN26
Entrez ID		7068	9659
HPRD ID		07521	10482
Ensembl ID		ENSG00000151090	ENSG00000178104
Uniprot IDs		A0A024R2I8 P10828	A0A075B749 A0A087WYE4 Q5VU43
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW
Enriched GO Terms of Interacting Partners?
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