THRB and NCOR1

Number of citations of the paper that reports this interaction (PubMedID 9121466)
54

Data Source:
BioGRID (pull down, far western blotting, affinity chromatography technology)
HPRD (in vitro, two hybrid)

		THRB	NCOR1
Description		thyroid hormone receptor beta	nuclear receptor corepressor 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Colorectal cancer ( 34062886) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)	Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494)
Interacting Genes		59 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PDE4DIP PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3	90 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RAI1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB7A ZMYND11
Entrez ID		7068	9611
HPRD ID		07521	02911
Ensembl ID		ENSG00000151090	ENSG00000141027
Uniprot IDs		A0A024R2I8 P10828	A0A024RD47 O75376 Q6PGR4
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW	2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6XXS 6XYX 6XZZ 6Y17 6ZBU
Enriched GO Terms of Interacting Partners?
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