TGFB2 and MARK1

		TGFB2	MARK1
Description		transforming growth factor beta 2	microtubule affinity regulating kinase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Platelet Alpha Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Skeletal System Development Eye Development Response To Hypoxia Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Hair Follicle Development Heart Morphogenesis Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Heart Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Neural Retina Development Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Cell Death Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Male Gonad Development Response To Xenobiotic Stimulus Response To Wounding Embryo Development Ending In Birth Or Egg Hatching Cardioblast Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Ascending Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Dopamine Biosynthetic Process Odontogenesis Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Negative Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Development Generation Of Neurons Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Regulation Of Cell Cycle Positive Regulation Of Cell Division Regulation Of Timing Of Catagen Positive Regulation Of Timing Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Uterus Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Secondary Palate Development Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Complement-dependent Cytotoxicity Substantia Propria Of Cornea Development Cranial Skeletal System Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization
Pathways		Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans
Drugs			Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density (hip) ( 30172743) Central corneal thickness ( 32528159 29760442) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease (severe) ( 24621683) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Intraocular pressure ( 29617998) Local histogram emphysema pattern ( 25006744) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes		17 interacting genes: APP BMP2 CCN2 DCN ENG FMOD KMT2A LTBP3 MARK1 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	16 interacting genes: CCDC102B CCR6 ESRRG GJA5 INCA1 KCNK2 MAP2 MAP4 MAPT NIBAN1 STK11 TAOK1 TCL1B TGFB2 USH2A YAF2
Entrez ID		7042	4139
HPRD ID		01828	07353
Ensembl ID		ENSG00000092969	ENSG00000116141
Uniprot IDs		P61812 Q59EG9	A0A087X0I6 A0A7I2YQC1 B4DIB3 Q9P0L2 X5D2M4
PDB IDs		1TFG 2TGI 4KXZ 5TX4 5TY4 6I9J	2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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