TFR2 and PRKAR2B

		TFR2	PRKAR2B
Description		transferrin receptor 2	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse
	Molecular Function	Transferrin Receptor Activity Protein Binding Metalloexopeptidase Activity Co-receptor Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Proteolysis Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Acute-phase Response Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation	Fatty Acid Metabolic Process Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Response To Clozapine Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Transferrin endocytosis and recycling	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Ferrous sulfate anhydrous Ferric derisomaltose	Cyclic adenosine monophosphate
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Eosinophil counts ( 32888494) Hematocrit ( 32888494 27863252 28017375 19862010) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 33536631 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494 27863252)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: HFE OLFM4 PRKAR2B SEC22A SOCS3 TF	26 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		7036	5577
HPRD ID		05282	01486
Ensembl ID		ENSG00000106327	ENSG00000005249
Uniprot IDs		Q9UP52	A0A024R712 B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?
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