TFR2

Description		transferrin receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Transferrin Receptor Activity Protein Binding Metalloexopeptidase Activity Co-receptor Binding
	Biological Process	Proteolysis Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Acute-phase Response Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation
Pathways		Transferrin endocytosis and recycling
Drugs		Ferrous sulfate anhydrous Ferric derisomaltose
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Eosinophil counts ( 32888494) Hematocrit ( 32888494 27863252 28017375 19862010) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 33536631 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		6 interacting genes: HFE OLFM4 PRKAR2B SEC22A SOCS3 TF
Entrez ID		7036
HPRD ID		05282
Ensembl ID		ENSG00000106327
Uniprot IDs		Q9UP52
PDB IDs
Enriched GO Terms of Interacting Partners?
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