TBL1X and TAB2

Number of citations of the paper that reports this interaction (PubMedID 12150997)
197

Data Source:
BioGRID (pull down)

		TBL1X	TAB2
Description		transducin beta like 1 X-linked	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Heart Development Negative Regulation Of Autophagy Response To Lipopolysaccharide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Refractive error ( 32231278)	Breast cancer ( 22383897 29059683) Coronary artery disease ( 33020668) Diverticulitis ( 28585551) Dupuytren's disease ( 28886342 21732829) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		30 interacting genes: ARL3 CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR IQCB1 KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	43 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143
Entrez ID		6907	23118
HPRD ID		02183	05483
Ensembl ID		ENSG00000101849	ENSG00000055208
Uniprot IDs		A0A024RBV9 O60907	B4DIR9 Q9NYJ8
PDB IDs		2XTC 2XTD 2XTE	2DAE 2WWZ 2WX0 2WX1
Enriched GO Terms of Interacting Partners?
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