KLF5 and ATXN3L

Number of citations of the paper that reports this interaction (PubMedID 26079537)
15

Data Source:
BioGRID (enzymatic study)

		KLF5	ATXN3L
Description		Kruppel like factor 5	ataxin 3 like
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus Mitochondrial Matrix Cytosol Mitochondrial Membrane Nuclear Inclusion Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding MRF Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Activity Thiol-dependent Deubiquitinase Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Organic Cyclic Compound Cell-cell Signaling Via Exosome Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Cell-substrate Adhesion Protein Deubiquitination Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H3 Deacetylation Cellular Response To Misfolded Protein
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis	Josephin domain DUBs
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 31959993) Keratoconus ( 33649486) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Prostate cancer ( 31562322 26443449) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)	Bipolar disorder ( 31043756)
Interacting Genes		27 interacting genes: ANP32B ATXN3L BAP1 CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I WWP1	8 interacting genes: KLF5 PJA1 RFFL TRIM54 TRIM55 TRIM63 UBC USP28
Entrez ID		688	92552
HPRD ID		04212	19697
Ensembl ID		ENSG00000102554	ENSG00000123594
Uniprot IDs		Q13887 Q5T6X2	B4DYC7 Q9H3M9
PDB IDs		2EBT	3O65
Enriched GO Terms of Interacting Partners?
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