KLF5 and SET

Number of citations of the paper that reports this interaction (PubMedID 14612398)
52

Data Source:
HPRD (in vitro, in vivo)

		KLF5	SET
Description		Kruppel like factor 5	SET nuclear proto-oncogene
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Golgi Apparatus Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding MRF Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Organic Cyclic Compound Cell-cell Signaling Via Exosome Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 31959993) Keratoconus ( 33649486) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Prostate cancer ( 31562322 26443449) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)	Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		27 interacting genes: ANP32B ATXN3L BAP1 CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I WWP1	69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 REPIN1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85
Entrez ID		688	6418
HPRD ID		04212	09023
Ensembl ID		ENSG00000102554	ENSG00000119335
Uniprot IDs		Q13887 Q5T6X2	A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3
PDB IDs		2EBT	2E50
Enriched GO Terms of Interacting Partners?
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