STAT6 and ZNF407

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		STAT6	ZNF407
Description		signal transducer and activator of transcription 6	zinc finger protein 407
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol Membrane Raft	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding	DNA Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Reactive Nitrogen Species	Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)	Estradiol levels ( 22675492) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRIM1 PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92	4 interacting genes: C1QTNF9 STAT6 ZBTB9 ZSCAN1
Entrez ID		6778	55628
HPRD ID		03302	11713
Ensembl ID		ENSG00000166888	ENSG00000215421
Uniprot IDs		A8K4S9 B4DQB3 H0YJH6 P42226	Q9C0G0
PDB IDs		1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX
Enriched GO Terms of Interacting Partners?
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