STAT6 and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 20121258)
17

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		STAT6	ANXA2
Description		signal transducer and activator of transcription 6	annexin A2
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol Membrane Raft	Ruffle Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Cortex Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Small GTPase Binding Identical Protein Binding S100 Protein Binding Bone Sialoprotein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Reactive Nitrogen Species	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Vesicle Budding From Membrane Body Fluid Secretion Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis Positive Regulation Of Vacuole Organization Positive Regulation Of Fibroblast Proliferation Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Response To Thyroid Hormone Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRIM1 PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92	46 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 YWHAQ ZBTB4
Entrez ID		6778	302
HPRD ID		03302	01061
Ensembl ID		ENSG00000166888	ENSG00000182718
Uniprot IDs		A8K4S9 B4DQB3 H0YJH6 P42226	A0A024R5Z7 H0YL33 P07355
PDB IDs		1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?