SSRP1 and MCM4

Number of citations of the paper that reports this interaction (PubMedID 16902406)
81

Data Source:
HPRD (in vivo)

		SSRP1	MCM4
Description		structure specific recognition protein 1	minichromosome maintenance complex component 4
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus FACT Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex CMG Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication DNA Repair Regulation Of Chromatin Organization	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		20 interacting genes: AURKA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AC20 H2BC21 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 UBE2I	27 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUMO2 SUPT16H TLX2
Entrez ID		6749	4173
HPRD ID		05061	09094
Ensembl ID		ENSG00000149136	ENSG00000104738
Uniprot IDs		A0A024R4Z6 Q08945	B3KMX0 B4DLA6 P33991
PDB IDs		4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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