MCM4 and SUPT16H

Number of citations of the paper that reports this interaction (PubMedID 16902406)
81

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		MCM4	SUPT16H
Description		minichromosome maintenance complex component 4	SPT16 homolog, facilitates chromatin remodeling subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex CMG Complex	Nucleoplasm FACT Complex
	Molecular Function	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	RNA Binding Protein Binding Nucleosome Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		27 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUMO2 SUPT16H TLX2	12 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A MCM3 MCM4 NEK9 NGDN PARP1 SREK1 SRPK2 SUMO2
Entrez ID		4173	11198
HPRD ID		09094	16088
Ensembl ID		ENSG00000104738	ENSG00000092201
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q9Y5B9
PDB IDs		6XTX 6XTY	4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL
Enriched GO Terms of Interacting Partners?
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