BPI and ATP6V0B

		BPI	ATP6V0B
Description		bactericidal permeability increasing protein	ATPase H+ transporting V0 subunit b
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Lipopolysaccharide Binding	Transporter Activity Protein Binding Proton Transmembrane Transporter Activity
	Biological Process	Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium	Regulation Of Macroautophagy Proton Transmembrane Transport
Pathways		Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine	Tiludronic acid
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		2 interacting genes: ATP6V0B PRSS2	34 interacting genes: ADGRG3 ADRB2 APOD BPI CCL19 COL4A5 DAPK2 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM RPS26P15 SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 TTC39A VMA21 YWHAE YWHAG ZFYVE9
Entrez ID		671	533
HPRD ID		00174	04759
Ensembl ID		ENSG00000101425	ENSG00000117410
Uniprot IDs		P17213	E9PNL3 Q99437
PDB IDs		1BP1 1EWF	6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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