SUMO3 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 22878415)
61

Data Source:
BioGRID (enzymatic study)

		SUMO3	SENP1
Description		small ubiquitin like modifier 3	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	SUMO is proteolytically processed RHOF GTPase cycle
Drugs
Diseases
GWAS		Delirium ( 29631748)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		55 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TRAPPC10 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496	25 interacting genes: APP CAV3 GCM1 HDAC1 HIPK1 HIPK2 KCNK1 KEAP1 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		6612	29843
HPRD ID		03754	07153
Ensembl ID		ENSG00000184900	ENSG00000079387
Uniprot IDs		P55854	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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