DDRGK1 and HTR6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		DDRGK1	HTR6
Description		DDRGK domain containing 1	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Protein Binding Ubiquitin-like Protein Ligase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Reticulophagy Protein Localization To Endoplasmic Reticulum Protein Ufmylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Metallopeptidase Activity Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Protein K69-linked Ufmylation	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		RHOA GTPase cycle	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		HDL cholesterol levels x loop diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to hepatitis C treatment ( 21659334) Ribavirin-induced anemia ( 20637204)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		5 interacting genes: APP FASTKD5 FBXO7 HTR6 TP53	32 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CD160 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		65992	3362
HPRD ID		12741	03066
Ensembl ID		ENSG00000198171	ENSG00000158748
Uniprot IDs		Q96HY6	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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