SLC22A4 and SLC9A3R2

Number of citations of the paper that reports this interaction (PubMedID 15553237)
13

Data Source:
HPRD (two hybrid)

		SLC22A4	SLC9A3R2
Description		solute carrier family 22 member 4	SLC9A3 regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Cation:cation Antiporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding
	Biological Process	Triglyceride Metabolic Process Sodium Ion Transport Body Fluid Secretion Carnitine Metabolic Process Organic Cation Transport Quaternary Ammonium Group Transport Carnitine Transport Xenobiotic Transport Amino Acid Import Across Plasma Membrane Carnitine Transmembrane Transport	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Organic cation transport
Drugs		Levocarnitine
Diseases
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Itch intensity from mosquito bite ( 28199695) Lymphocyte counts ( 32888494) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Platelet count ( 32888494) Serum metabolite levels ( 33031748 23093944) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)	Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		5 interacting genes: PDZD3 PDZK1 PVR SLC9A3R1 SLC9A3R2	43 interacting genes: ABCC4 ACE2 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TRAF4 WWP2 WWTR1
Entrez ID		6583	9351
HPRD ID		09171	05946
Ensembl ID		ENSG00000197208	ENSG00000065054
Uniprot IDs		Q9H015	Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?
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