SLC22A3 and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 15553237)
13

Data Source:
HPRD (two hybrid)

		SLC22A3	PDZD3
Description		solute carrier family 22 member 3	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Neuronal Cell Body Presynapse	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell
	Molecular Function	Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding
	Biological Process	Histamine Metabolic Process Neurotransmitter Transport Organic Cation Transport Quaternary Ammonium Group Transport Organic Anion Transport Monocarboxylic Acid Transport Monoamine Transport Regulation Of Appetite Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Epinephrine Uptake Purine-containing Compound Transmembrane Transport Dopamine Uptake Transport Across Blood-brain Barrier Toxin Transport	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane
Pathways		Abacavir transmembrane transport Organic cation transport	Intestinal infectious diseases
Drugs
Diseases
GWAS		Body fat percentage and LDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 26426971 28892062) Body mass index (age>50) ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and LDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index x sex x age interaction (4df test) ( 26426971) Body shape index ( 34021172) Colorectal cancer ( 21242260) Coronary artery disease ( 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611) Estimated glomerular filtration rate ( 31015462) Glycine levels ( 30837465) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma plasminogen levels ( 25208887) Prostate cancer ( 18264097 26034056 25939597 27262462) Pulse pressure ( 30224653) Response to hepatitis C treatment ( 22095909) Type 2 diabetes ( 30054458 30297969 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: PDZD3	21 interacting genes: ABCC2 ASAP3 CACNA1S CFTR FCER1G GUCY2C NLRX1 NOMO1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8
Entrez ID		6581	79849
HPRD ID		05328	06191
Ensembl ID		ENSG00000146477	ENSG00000172367
Uniprot IDs		O75751	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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