BMPR1A and GALNT12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		BMPR1A	GALNT12
Description		bone morphogenetic protein receptor type 1A	polypeptide N-acetylgalactosaminyltransferase 12
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Phosphatase Activator Activity BMP Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Metal Ion Binding BMP Receptor Activity Transcription Regulator Activator Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Stem Cell Population Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Heart Formation Atrioventricular Node Cell Development BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Senescence	O-glycan Processing
Pathways		Signaling by BMP	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
Drugs		Dibotermin alfa
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Asthma ( 31959851) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Leftâ€“right brain asymmetry ( 33723403) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824)
Interacting Genes		45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TDGF1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		657	79695
HPRD ID		03192	13561
Ensembl ID		ENSG00000107779	ENSG00000119514
Uniprot IDs		P36894	Q8IXK2
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4	6PXU
Enriched GO Terms of Interacting Partners?
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