SLC4A1 and CFHR5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC4A1	CFHR5
Description		solute carrier family 4 member 1 (Diego blood group)	complement factor H related 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle	Extracellular Region Protein-containing Complex
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Transmembrane Transporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity	Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Anion Transport Chloride Transport Cellular Ion Homeostasis Blood Coagulation Bicarbonate Transport Plasma Membrane Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Ion Homeostasis Negative Regulation Of Oxidoreductase Activity Regulation Of Intracellular PH Transmembrane Transport Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Complement Activation, Alternative Pathway Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Regulation of Complement cascade
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Urate levels ( 31578528)	Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (MTAG) ( 32277175) Asthma ( 29273806) Blood protein levels ( 29875488 28240269) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		18 interacting genes: ACTC1 ADAM33 ANK1 BLOC1S6 BMP10 CA2 CA4 CANX CDKN2A CFHR5 EPB41 EPB42 LYN RHAG SLC4A1AP SYK TMEM60 ZBTB14	20 interacting genes: ARL13B C3 CISD2 CREB3 CREB3L1 EBAG9 ERGIC3 FFAR2 GPX8 KCNK7 LMNA MFSD14B PANX1 SLC10A1 SLC18A2 SLC4A1 STOM TMEM14B TMEM237 TMPRSS2
Entrez ID		6521	81494
HPRD ID		00175	06508
Ensembl ID		ENSG00000004939	ENSG00000134389
Uniprot IDs		P02730	Q9BXR6
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?