CFHR5 and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CFHR5	TMPRSS2
Description		complement factor H related 5	transmembrane serine protease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Protein-containing Complex	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Complement Activation, Alternative Pathway Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell
Pathways		Regulation of Complement cascade	Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			Camostat
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (MTAG) ( 32277175) Asthma ( 29273806) Blood protein levels ( 29875488 28240269) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		20 interacting genes: ARL13B C3 CISD2 CREB3 CREB3L1 EBAG9 ERGIC3 FFAR2 GPX8 KCNK7 LMNA MFSD14B PANX1 SLC10A1 SLC18A2 SLC4A1 STOM TMEM14B TMEM237 TMPRSS2	60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1
Entrez ID		81494	7113
HPRD ID		06508	03637
Ensembl ID		ENSG00000134389	ENSG00000184012
Uniprot IDs		Q9BXR6	O15393
PDB IDs
Enriched GO Terms of Interacting Partners?
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