CRTC3 and SIK2

Number of citations of the paper that reports this interaction (PubMedID 29211348)
20

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CRTC3	SIK2
Description		CREB regulated transcription coactivator 3	salt inducible kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of CREB Transcription Factor Activity Macrophage Activation Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Energy Homeostasis	Protein Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Heme signaling
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chromium levels ( 26025379) Chronic postoperative pain ( 31903573) Colorectal cancer ( 29228715) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 27485664) Heel bone mineral density ( 28869591) Inflammatory bowel disease ( 28067908 23128233) Information processing speed ( 21130836) Male-pattern baldness ( 28196072) Offspring birth weight ( 31043758) Response to exercise (triglyceride level interaction) ( 26491034) Ulcerative colitis ( 28067908)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: AEN C15orf32 CA13 HAPLN3 KLHL12 RCCD1 RGMA SIK2 TICRR UNC45A WDR93 YWHAG	7 interacting genes: APP CRTC2 CRTC3 FBXW7 GABARAPL2 HDAC5 IRS1
Entrez ID		64784	23235
HPRD ID		13384	12348
Ensembl ID		ENSG00000140577	ENSG00000170145
Uniprot IDs		Q6UUV7 Q8TEF4	A0A024R3G7 Q9H0K1
PDB IDs
Enriched GO Terms of Interacting Partners?
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