SIAH2 and DCC

  • Number of citations of the paper that reports this interaction (PubMedID 9858595)
  • 78
  • Data Source:
  • HPRD (in vitro)

SIAH2

DCC

Description siah E3 ubiquitin protein ligase 2 DCC netrin 1 receptor
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 27089180 34211149)
  • Alcoholism (alcohol use disorder factor score) ( 21529783)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Benign prostatic hyperplasia ( 30988330)
  • Body mass index ( 28892062)
  • Body mass index (ever vs never smoking interaction) ( 23192594)
  • Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148)
  • Brain morphology (MOSTest) ( 32665545)
  • Chronic back pain ( 30261039)
  • Coenzyme Q10 levels ( 27149984)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Depression ( 27089181 33859377 29700475)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling miserable ( 29500382)
  • Gallbladder cancer ( 22318345)
  • Gastroesophageal reflux disease ( 34187846)
  • General cognitive ability ( 29844566)
  • General factor of neuroticism ( 30867560)
  • Glucose homeostasis traits ( 25524916)
  • Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821)
  • Homeostasis model assessment of insulin resistance ( 33381925)
  • Household income (MTAG) ( 31844048)
  • Intelligence (MTAG) ( 29326435)
  • Intraocular pressure ( 30591961)
  • Lung function (FVC) ( 30061609 30804560)
  • Mood instability ( 31168069 29187730)
  • Mosquito bite size ( 28199695)
  • Multisite chronic pain ( 33830993 31194737)
  • Neurociticism ( 29500382)
  • Nickel levels ( 26025379)
  • Number of sexual partners ( 30643258)
  • Obesity-related traits ( 23251661)
  • Putamen volume ( 29147026)
  • Response to exercise (triglyceride level interaction) ( 26491034)
  • Response to fenofibrate (total cholesterol levels) ( 27002377)
  • Response to mTOR inhibitor (everolimus) ( 24009623)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Schizophrenia ( 33169155 30285260)
  • Short-term memory (digit-span task) ( 30741946)
  • Smoking behaviour (cigarettes smoked per day) ( 27393504)
  • Smoking initiation ( 33082346)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Subcortical brain region volumes ( 25607358)
  • Survival in colorectal cancer (distant metastatic) ( 26586795)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes 44 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1 38 interacting genes: ADORA2B AFDN-DT ALDOB ANP32B APPL1 AR ARG2 BARD1 CASP3 CASP9 CORO2A CTSV FBP1 FECH GPI HEMGN MAPK3 MAZ NARS1 NCK1 NSDHL NTN1 PITPNA POLR2E PTK2 RASA1 RPL5 SERPINB2 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TNNI1 TRMO TSTD2 TULP4
Entrez ID 6478 1630
HPRD ID 03737 00391
Ensembl ID ENSG00000181788 ENSG00000187323
Uniprot IDs O43255 P43146 Q49AK4
PDB IDs 5H9M 2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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